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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Neuropharmacology. 2013 Aug 23;76(0 0):301–319. doi: 10.1016/j.neuropharm.2013.08.014

Figure 1.

Figure 1

Abstinence-dependent changes in 5-HT1BR manipulations on cocaine SA under a PR schedule of reinforcement in male rats. Viral vectors containing GFP (Con) or 5-HT1BR+ GFP (5-HT1B-V) transcripts were infused into the NAc either during maintenance (left) or after 21 days of protracted abstinence (right). Rats were tested for the effects of the virus 4 days later on an exponential PR schedule of cocaine reinforcement (0.75 mg/kg, IV). The 5-HT1BR agonist CP94253 (5.6 mg/kg) or saline (Con) was administered on abstinence day 21 and the test for responding on the exponential PR schedule of reinforcement began 15 min later. *different from Con, p<0.05. The effects of viral over-expression of 5-HT1BRs has been published previously (Pentkowski et al., 2012).