Table 2.
Mutations found in pyrE and pyrF genes
| Strain | Gene | Sequencea | Amino acid change |
|---|---|---|---|
| Wild type | pyrE | 254 CCCGGTT 260 | |
| E22 | pyrE | 254 CCCaGTT 260 | R86Q |
| Wild type | pyrE | 113 TCGAAGC 119 | |
| E24 | pyrE | 113 TCGgAGC 119 | E39G |
| Wild type | pyrF | 385 GCTGGGG 391 | |
| E21, E23, E41 | pyrF | 385 GCT-GGG 390 | Frame shift |
| E25, E26 | pyrF | 385 GCTgGGGG 392 | Frame shift |
a
A lower case letter indicates nucleotide substitution or insertion; a hyphen indicates deletion; numbers indicate position of the nucleotide relative to the first position of the translation initiation codon.