Skip to main content
. Author manuscript; available in PMC: 2014 Jun 2.
Published in final edited form as: Mol Nutr Food Res. 2011 May 2;55(7):1070–1078. doi: 10.1002/mnfr.201000640

Figure 8.

Figure 8

Putative mechanisms for DON-induced weight loss in HF-induced obese mice. DON induces reduced food intake, possibly via serotonin-mediated modulation of appetite in the brain or other mechanism. Reduced calorie intake can result in decreased plasma insulin and IGF-1/IGFALS. DON might also downregulate insulin and IGF-1/IGFALS by upregulating COX-2/PGE2 and IL-6, respectively. Downregulation of these hormones can contribute to decreased body fat mass and prevent further increase in lean mass, ultimately decreasing body weights of HF-induced obese mice. Another downstream effect is downregulation of leptin, which can increase expression of the orexigenic peptide AgRP and facilitate partial recovery of food intake.