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. Author manuscript; available in PMC: 2015 Jan 20.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Dec 11;53(4):1140–1143. doi: 10.1002/anie.201308607

Scheme 1.

Scheme 1

Structures of the fibrin imaging probe EP-2104R and the mixed disulfide 1, which can be converted to EP-2104R through the enzymatic activity of PDI. Compound 2 is a non-binding analogue to 1 that is not a substrate for PDI and serves as a negative control.