Table 2.
Trials comparing shortcourse preoperative radiotherapy (5X5 Gy) with preoperative chemoradiation.
| Trial | No | Stage | chemo | Adjuvant chemotherapy | Local recurrence | RFS/DFS | 5 year OS |
|---|---|---|---|---|---|---|---|
| Polish SCPRT | 155 | cT3-T4 | none | Optional | Crude 9% | 4 year DFS 58% | 4 year OS 67% |
| Polish CRT | 157 | cT3-T4 | 5FU/FA | Optional | Crude 14% | 4 year DFS 56% | 4 year OS 66% |
| TROG SCPRT | 163 | II-III | none | Mandated FUFA 6/12 | 3 years 7.5% | 5 year RFS 64% | 5 year 74% |
| TROG SCPRT | 163 | II-III | PVI 5FU 225mg/m2 | Mandated FUFA 4/12 | 3 years 4.4% | 5 year RFS 61% | 5 year 70% |
| Latkauskas SCPRT | 37 | II-III | none | Not stated | Not stated | Not stated | Not stated |
| Latkauskas CRT | 46 | II-III | 5FU/FA | Not stated | Not stated | Not stated | Not stated |
| Pach 2012 SCPRT immediate 7-10 days | 77 | I-III | none | Not stated | 1.5% | Not stated | 63% |
| Pach 2012 SCPRT delayed 4-5 weeks | 77 | I-III | none | Not stated | 7% | Not stated | 73% |
SCPRT = short course preoperative radiotherapy; CRT = chemoradiation; RFS/DFS relapse free survival/disease free survival; OS = overall survival; FUFA = 5FU and folinic acid.