Table 1. Comparison of impaired bacterial clearance in wild-type and TLR9−/− MEs.
Time after NTHi instillation | C57BL/6 | TLR9−/− |
---|---|---|
Day 1 | 4/6 | 3/6 |
Day 2 | 6/6 | 4/6 |
Day 3 | 3/6 | 3/6 |
Day 5 | 0/6 | 2/6 |
Day 10 | 0/6 | 2/6 |
Day 14 | 0/6 | 0/6 |
Bacterial colonization of the culture positive plates was evaluated using semi-quantitative analysis of bacterial colonization: 0 indicates no CFUs, 1 indicates one quadrant with CFUs, 2 indicates two quadrants with CFUs, 3 indicates three quadrants with CFUs and 4 indicates four quadrants with CFUs. Data represent positive culture plates out of six.