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. 2014 May 9;42(10):6542–6551. doi: 10.1093/nar/gku235

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — RNAi activity of siRNAs with amide modifications in the guide strand. The results are expressed as ratios of target mRNA expression (PPIB) and housekeeping mRNA expression (GAPDH) and are averages of three replicates; the standard deviations are shown in the length of the error bars. Control P and Control OH are unmodified siRNAs with 5′-phosphate or 5′-OH, respectively. NTC is a non-targeting control siRNA used as a negative control; t_m values are the melting temperatures of the siRNA duplexes.