Table 2.

Pre-steady-state kinetic parameters of TDG-catalyzed excision of T opposite to various DNA adducts

Substratea	kobs (min−1)b
T•G (CXG)	0.165 ± 0.014
T•Hx (CXG)	0.066 ± 0.008
T•ϵA DL (CXC)	0.042 ± 0.012
T•THF (CXC)	0.027 ± 0.006
T•8oxoA (CXC)	0.006 ± 0.001

^aLetters within the parentheses represent nearest neighbor nucleotide sequence context where X is G, Hx, ϵA, THF or 8oxoA.

^bConstants were calculated by one-phase exponential association equation using GraphPad Prism 5.