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. 2014 Apr 11;42(10):6168–6182. doi: 10.1093/nar/gku253

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The C-terminal region of KDM4C mediates its association with mitotic chromatin. Panels (A)–(D) show that the C-terminus of KDM4C, containing the two Tudor domains, is essential and sufficient for its association with mitotic chromatin. Panels (E)–(F) show that the distal Tudor domain is essential but not sufficient for the localization of KDM4C at mitotic chromatin. In panels (A)–(F), U2OS cells were transfected with expression constructs encoding the indicated chimeras fused to EGFP (green). DNA is stained with DAPI (blue). Results are typical of 2–3 different experiments and each image represents at least 10 different cells. Image acquisition and scoring were performed by a student who was blind of the experimental condition.