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. 2014 Apr 21;42(10):6421–6435. doi: 10.1093/nar/gku280

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — CNV of the tRNA tandem repeat. (a) Schematic map covering genomic coordinates 161,400,901–161,460,900 of chromosome 1 from build GRCh37/hg19. The black right-facing arrows indicate the location of the tRNA repeat. The location of tRNA genes and LTR elements are indicated beneath this, followed by the location of the 519 bp probe. (b) Restriction map of the same interval showing the location of all XbaI recognition sites. (c) CNV of the tRNA repeat. Images show Southern blot hybridization of XbaI cut DNA from 33 unrelated individuals, separated by PFGE and hybridized with the 519 bp probe. The ethnicity of samples is indicated above each lane (UM, Utah Mormon; Han Chin, Han Chinese; Af. American, African American; G. Indian, Gujarat Indian). Samples of unknown ethnic origins are labeled according to their corresponding cell type. The migratory size of molecular weight marker fragments is indicated on the left.