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. 2014 May 12;42(10):6106–6127. doi: 10.1093/nar/gku284

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — A two-step model for the double-strand break (DSB) end resection. Proteins represented in different colours are recruited at different stages. a) The first step, 'initial resection', is carried out by the endonuclease activity of the MRN (MRE11–AD50–NBS1) complex and promoted by CtIP. Multiple regulatory mechanisms, especially the cell cycle-dependent regulation are involved. b) The second step, long-range resection, is performed by EXO1 or BLM in concert with DNA2. It remains unclear whether EXO1 and BLM work in parallel or interact.