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. 2014 May 12;42(10):6106–6127. doi: 10.1093/nar/gku284

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The single-strand annealing (SSA) sub-pathway of homologous recombination. This is a Rad51-independent sub-pathway of HR, which operates when there are regions of homology or direct repeats at both sides of the DSB. a) SSA is initiated by RAD52 that binds the 3′ ssDNA ends generated by DSB end resection. RAD52 then functions in concert with RPA to facilitate strand annealing between the two direct repeats. b) Next, the XPF–ERCC1 heterodimers remove the non-homologous 3′ single-stranded flaps between the two repeats. c) The two DSB ends are re-joined by DNA ligase III. d) The sequence continuity is restored.