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The Alternative NHEJ (A-NHEJ). Proteins represented in different colours are recruited at different stages. In A-NHEJ, a) the broken ends are detected and bound by PARP1. b) This is followed by end-processing by MRN, CtIP and BRCA1, which is prohibited by 53BP1. c) The ligation step can be performed by either LIG3 in concert with XRCC1, or LIG1. d) The sequence continuity is restored.
