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. Author manuscript; available in PMC: 2014 Jun 2.
Published in final edited form as: J Am Coll Cardiol. 2012 Oct 16;60(16):1558–1565. doi: 10.1016/j.jacc.2012.05.049

Table 3.

Univariate and Multivariate Analysis in Normotensive and Pre-Hypertensive Subjects

Biomarker Univariate Model
(� ± SE)		 Model 1
(� ± SE)		 Model 2
(� ± SE)		 Model 3
(� ± SE)		 Model 4
(� ± SE)		 Model 5
(� ± SE)
Log proBNP1–108 0.06 ± 0.07 −0.07 ± 0.06 −0.04 ± 0.06 −0.04 ± 0.06 −0.04 ± 0.06 −0.04 ± 0.06
Log BNP1–32 (Shionogi) −0.00 ± 0.06 −0.12 ± 0.05* −0.11 ± 0.05* −0.11 ± 0.05* −0.11 ± 0.05* −0.11 ± 0.05*
Log BNP1–32 (Biosite) −0.02 ± 0.07 −0.13 ± 0.06* −0.12 ± 0.06 −0.12 ± 0.06 −0.12 ± 0.06 −0.12 ± 0.06*
Log NT-proBNP1–76 (Roche) −0.01 ± 0.07 −0.15 ± 0.06* −0.13 ± 0.06* −0.14 ± 0.06* −0.13 ± 0.06* −0.14 ± 0.06*
Log ANP1–28 (Phoenix Pharmaceuticals) 0.02 ± 0.04 −0.01 ± 0.04 −0.00 ± 0.04 −0.01 ± 0.04 −0.01 ± 0.04 −0.01 ± 0.04
Log NT-ANP1–98 (Phoenix Pharmaceuticals) −0.03 ± 0.04 −0.11 ± 0.03* −0.09 ± 0.03* −0.08 ± 0.04* −0.08 ± 0.03* −0.08 ± 0.03*

Values are 1 ± SE in contrast to normotensive subjects. Model 1 = age+age2+sex; Model 2 = age+age2+sex+BMI; Model 3 = age+age2+sex+BMI+LVH; Model 4 = age+age2+sex+BMI+LVH+creatinine; Model 5 = hypertension+age+age2+sex+BMI+LVH+creatinine+number of antihypertensive medications.

^

Logarithm of BNP and ANP values used to satisfy regression assumptions.

*

p < 0.05,

**

p < 0.001 compared with normotensive subjects.

Abbreviations as in Table 1.