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KCNJ5 mutations result in depolarization of the current reversal potential. Reversal potentials are plotted for WT KCNJ5/KCNJ3 channels and each KCNJ5 mutation/KCNJ3. Normal sequence (wild-type) channels (open bar) show a negative reversal potential. Mutant channels (gray bars) show less negative reversal potentials (P<0.05 in each case), suggesting a loss of ion selectivity. Numbers in parentheses are the number of cells recorded. G151R1:G/A, G151R2:G/C.
