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. Author manuscript; available in PMC: 2014 Jun 2.
Published in final edited form as: Genes Chromosomes Cancer. 2013 Apr 30;52(7):675–682. doi: 10.1002/gcc.22063

Figure 2.

Figure 2

LIFR-PLAG1 gene fusion in a soft tissue myoepithelial tumor (ME4). (A) Gross appearance of this well-circumscribed, yellow-tan, firm, hand subcutaneous lesion, arising in a 64 year-old female. The histologic spectrum of this tumor is quite broad, including: (B) ducts lined by columnar cells with abundant mucin-containing cytoplasm and basally-located nuclei; C. tubular structures lined by bland cuboidal epithelial cells; (D) Sheets of myoepithelial cells, with a distinctive rhabdoid or plasma-cell phenotype, showing densely eosinophilic cytoplasm and eccentric round nuclei. E.ABI sequence of 5’RACE product showed the presence of a fusion between LIFR exon 1 to PLAG1 exon 2; F. FISH showing a LIFR gene break-apart signal (telomeric probe , green; centromeric probe, orange).