QUANTEC Summary Table.

Approximate Dose/Volume/Outcome Data for Several Organs Following Conventional Fractionation (Unless Otherwise Noted)^{^}

^{^}All data are estimated from the literature summarized in the QUANTEC reviews (unless otherwise noted). Clinically, these data should be applied with caution. Clinicians are strongly advised to use the individual QUANTEC articles to check the applicability of these limits to the clinical situation at hand. They largely do not reflect modern IMRT.

^*all at standard fractionation (i.e. 1.8 -2.0 Gy per daily fraction) unless otherwise noted.

^**non-TBI

^***with combined chemotherapy

^****Dx = minimum dose received by the “hottest” x% (or x cc’s) of the organ

^*****Severe xerostomia is related to additional factors including the doses to the submandibular glands.

^aEstimated by Dr. Eisbruch

^bClassic RT-induced liver disease (RILD) involves anicteric hepatomegaly and ascites, typically occurring between 2 weeks to 3 months after therapy. Classic RILD also involves elevated alkaline phosphatase (more than twice the upper limit of normal or baseline value).

^#For optic nerve, the cases of neuropathy in the 55-60 Gy range received ~59 Gy (see optic nerve paper for details). Excludes patients with pituitary tumors where the tolerance may be reduced.