Table 1. The eighty most regulated genes.

Groups	Up-regulated	Down-regulated
Cas	Ska3/LOC689296/LOC681325 Aspn/RGD1562462/Slamf9 Ifit1/Kcnd2/Rnase2/Rpl21	Ocm/Furin/Isyna1 LOC287167/Aox3/Dmd/Slc17a9 Tomm7/Tnnt2/Hspb6
E2	Ankrd11/N5/Hamp/Sft2d1 LOC691979/nucleolin/Tns4 Slc39a1/Dync2h1/LOC290071	Sparc/Slc25a24/Susd2/Lcn2 Ly6c/Pi16/Glrx1/Kcnmb1 C1H6orf35/Tmem47
Cas+E2	Sh3rf2/LOC310926/Macc1/Chi3l1/Krt15/LOC259246 Rnase1l1/Sdr16c5/Obp3/Prol1	Mrpl41/Sms/Defb50/Hectd2 MGC109340/Scnn1g/Me1 V1rd15/Twf1/Pmp22
Shared	RGD1565682/Cfh/Gnat2 Lrrc34/Mmp12/Gpnmb/Abcc3/V1rk2/Blnk/Mmp15	Ugt2b34/Cntn6/Cyp2c13 Oas1k/Neto2/Cpa6/Cdh12 Wfdc3/Lrrc37a/Ldoc1

The ten most up- or down-regulated genes that were exclusive to each of the experimental groups or were shared by the three treatments. These genes are involved in different functions (see Appendix 1 for details on the annotated functions for these genes).