Table 3.
Plasma insulin level
|
Plasma insulin (ng/ml) | |||||
|---|---|---|---|---|---|
| Group | Dose (mg/kg) |
Pre-induction |
Post-induction |
Week-4 |
% change after treatment |
| (Mean + SE) | (Mean + SE) | (Mean + SE) | |||
| Vehicle (-alloxan) |
0 |
1.25 ± 0.27 |
1.23 ± 0.29 |
4.26 ± 0.36 |
246.3 ↑ |
| UP780 (-) |
2000 |
0.99 ± 0.14 |
0.99 ± 0.27 |
4.12 ± 0.39 |
316.2 ↑ |
| Vehicle (+alloxan) |
0 |
1.78 ± 0.27 |
1.50 ± 0.34 |
1.99 ± 0.24 |
32.7 ↑ |
| Glyburide (+) |
5 |
1.87 ± 0.33 |
1.10 ± 0.15 |
1.76 ± 0.50 |
60.0 ↑ |
| UP780 (+) |
2000 |
1.96 ± 0.31 |
1.48 ± 0.33 |
2.37 ± 0.41 |
60.1 ↑ |
| UP394 (+) |
80 |
2.48 ± 0.5 |
1.68 ± 0.48 |
1.60 ± 0.37 |
4.8 ↓ |
| Qmatrix (+) | 1920 | 1.89 ± 0.28 | 1.50 ± 0.21 | 1.69 ± 0.32 | 12.7 ↑ |
Insulin dependent diabetes was induced by administering a single intraperitoneal injection of alloxan monohydrate at a dose of 150 mg/kg to CD-1 mice. Measurements for plasma insulin were taken at pre-induction, week-0 (baseline), and week-4 after treatment. Data are expressed as mean ± SD as well as percent change of treatment. ↑ increase from post induction, ↓ decrease from post induction.