. Author manuscript; available in PMC: 2014 Jun 2.

Published in final edited form as: Ann Surg Oncol. 2013 Sep 18;21(3):862–867. doi: 10.1245/s10434-013-3266-1

TABLE 3.

Summary of postoperative adjuvant therapy trials in pancreas cancer

Variable	Study
	ESPAC-1⁸		CONKO-001^5,13		ESPAC-3⁶		RTOG 97-04¹⁴		Current study
	5FU	CRT	GEM	Obs	5FU	GEM	5FU/CRT	GEM/CRT	Obs	CT	CRT
% R1	19	19	19	15	35	35	33	35	22	16	29
% LN positive	53	50	71	73	70	73	65	68	63	61	57
% LR	35		34	41	NR	NR	28	23	33	27	34
mOS (m)	20.1	15.9	22.5	20.2	23	23.6	16.9	20.6	6.3	21.5	16.8
mDFS (m)	NR	NR	13.4	6.9	14.1	14.3	11.1	11.2	NA	NA	NA
% G3-4 toxicity	4	6	5	1	14	7.5	62	79	NA	NA	NA

5FU 5-fluorouracil, CRT chemoradiation, GEM gemcitabine, Obs observation, R1 microscopically positive margins, LN lymph node, LR local recurrence, OS overall survival, DFS disease-free survival, CT chemotherapy, NA not available