TABLE 3.
Univariable |
Multivariablea |
|||
---|---|---|---|---|
HR (95 % CI) | P value | HR (95 % CI) | P value | |
Sex | ||||
Female | 1.00 (referent) | 1.00 (referent) | ||
Male | 0.96 (0.41–2.27) | 0.93 | 0.67 (0.12–3.84) | 0.65 |
Age at diagnosis (years) | ||||
<40 | 1.00 (referent) | 1.00 (referent) | ||
40–49 | 0.62 (0.23–1.68) | 0.97b | 0.52 (0.07–4.16) | 0.99b |
≥50 | 1.36 (0.42–4.34) | 1.84 (0.17–20.14) | ||
Country of recruitment | ||||
Australia and New Zealand | 1.00 (referent) | 1.00 (referent) | ||
Canada | 0.82 (0.24–2.75) | 0.75 | 7.63 (0.25–232) | 0.24 |
United States | 0.71 (0.27–1.86) | 0.48 | 0.84 (0.24–2.96) | 0.79 |
Cigarette smoking | ||||
Never user | 1.00 (referent) | 1.00 (referent) | ||
Ever user | 1.06 (0.44–2.57) | .90 | 0.84 (0.17–4.18) | 0.83 |
Synchronous tumor | ||||
Absent | 1.00 (referent) | 1.00 (referent) | ||
Present | 5.65 (0.67–47.68) | 0.11 | 11.54 (1.06–125) | 0.04 |
Maximum dimension of tumor (per cm) | 1.04 (0.86–1.25) | 0.72 | 0.93 (0.65–1.32) | 0.68 |
AJCC stage of tumor (per stage) | 1.68 (0.84–3.36) | 0.14 | 6.14 (1.21–13.14) | 0.03 |
Histological grade (per grade) | 1.48 (0.85–2.57) | 0.17 | 2.00 (0.61–6.53) | 0.25 |
AJCC the American Joint Committee on Cancer
Adjusted for variables in the table and taken account into familial correlation
P trend: calculated from Cox regression models with ordinal variables as continuous measures