Table 6. Distribution of the seven generic terms among the 50 top pathways in the enrichment analyses of the 13 gene lists.

	signature name	No. ofgenes	cytoskeletonremodeling		celladhesion		cellcycle		neurophysio- logicalprocess		musclecontraction		immuneresponse		development		sum ofpathways
			total	%	total	%	total	%	total	%	total	%	total	%	total	%	total	%
based on GWAS data	0.01 gene list	737	6	12	6	12	0	0	6	12	3	6	1	2	7	14	29	58
commercially used gene signatures	Mammaprint	70	1	2	3	6	3	6	5	10	2	4	3	6	12	24	29	58
	Oncotype DX	21	5	10	4	8	9	18	1	2	0	0	1	2	10	20	30	60
	MapQuant	97	4	8	1	2	17	34	0	0	0	0	2	4	1	2	25	50
	Gene Search	76	2	4	3	6	9	18	2	4	0	0	6	12	6	12	28	56
	Wound responsesignature	512	5	10	3	6	3	6	0	0	0	0	4	8	4	8	19	38
special metastasis gene signatures	Lung metastasissignature	54	4	8	5	10	0	0	0	0	0	0	16	32	11	22	36	72
	Brain metastasissignature	243	2	4	6	12	0	0	0	0	1	2	18	36	11	22	38	76
	Bone metastasissignature	102	6	12	4	8	0	0	0	0	0	0	14	28	11	22	35	70
general metastasis gene signatures	Invasivenesssignature	186	4	8	1	2	1	2	1	2	0	0	8	16	7	14	22	44
	Generalmetastasissignature	128	4	8	4	8	8	16	2	4	3	6	4	8	5	10	30	60
derived from meta-analyses	Meta genesignature	376	0	0	0	0	17	34	0	0	0	0	5	10	3	6	25	50
	374 GeneSet/consensusgenes	374	5	10	3	6	17	34	0	0	0	0	3	6	3	6	31	62