Figure 5. Phylogeny of a) CAV8 and b) CBV2 based on the partial VP1 region constructed by the neighbor-joining (NJ) algorithm implemented in MEGA version 5.0 using the Kimura two-parameter substitution model and 1000 bootstrap pseudo-replicates.

Strains from HFMD patients are indicated in pink, herpangina patients in blue, and influenza like illness patients in red.