Figure 6. Effects of 24R-epimer and 24S-epimer on the transport of P-gp substrate digoxin across Caco-2 cell monolayers.

Cells were preincubated for 1-epimer (1 and 10 µM) or 24S-epimer (1 and 10 µM), and followed by co-incubation for 2 h in the presence of 5 µM digoxin. Data are the mean ± S.E. of three independent experiments. ^* p<0.01 versus control, ^# p<0.01 between groups.