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. Author manuscript; available in PMC: 2014 Jun 2.
Published in final edited form as: Travel Med Infect Dis. 2013 Oct 30;12(3):268–273. doi: 10.1016/j.tmaid.2013.10.010

Figure 1.

Figure 1

Centers for Disease Control and Prevention diagnostic algorithms for syphilis. In the traditional algorithm, a screening quantitative RPR is followed by a confirmatory treponemal assay. In the reverse algorithm, an EIA or CIA specific for Treponema pallidum replaces the RPR as the screening test; a positive EIA or CIA is followed by a confirmatory RPR. If that RPR is negative, a second treponemal test is performed to verify the results. RPR = rapid plasma reagin; TP-HA = T. pallidum hemoagglutination test; TP-PA = T. pallidum particle agglutination test; EIA = enzyme immunoassay; CIA = chemiluminescence immunoassay.