. Author manuscript; available in PMC: 2015 Jun 15.

Published in final edited form as: Adv Drug Deliv Rev. 2014 Jan 22;0:94–109. doi: 10.1016/j.addr.2014.01.008

Table 3.

Example different tracers that have been delivered across the BBB

Agent	Size	Use
Lanthanum chloride	139 Da	Electron microscopy tracer [109]
99mTc-Diethylenetriaminepentaacetic pentaacetate	492 Da	SPECT agent [190]
Omniscan® (Gd-DTPA-BMA)	574 Da	MRI contrast agent [89]
Magnevist® (Gd-DTPA)	928 Da	MRI contrast agent [77]
Trypan blue, Evans blue	~67 kDa	Tissue dyes (binds to albumin) [79,191]
Ablavar® (Gadofosveset trisodium)	~67 kDa	MRI contrast agent (binds to albumin) [79]
Horseradish peroxidase	40 kDa	Electron microscopy tracer [78]
Dextran	3–70 kDa	Fluorescent tracer [136]
Immunoglobulin G	~150 kDa	Endogenous antibodies [157]
pCMV-EGFP¹	?	PlasmidDNA [192]
MION-47	20 nm	MRI contrast agent [120]
Gold nanoparticles	50 nm	Carrier for drugs or imaging [193]
Gold nanorods	10×40 nm	Photoacoustic imaging contrast agent [194]
Dotarem, P846, P792, P904, P03680	1–65 nm	MRI contrast agents [115]

Loaded into a microbubble