Table 6. Iridocyclitis, cataract, papillitis and chorioretinitis in onchocerciasis patients (n = 82) post ivermectin treatment. Differences were evaluated using Pearson's chi-square test.
| right EYE | left EYE | |||||
| before ivermectin | 4 years PIT$ | 23 years PIT | before ivermectin | 4 years PIT | 23 years PIT | |
| Iridocyclitis | ||||||
| 1/2 Mydriase (in %) | 1 (1) | 1(1) | 1 (1) | 1 (1) | 1 (1) | 1 (1) |
| Iris Normal (in %) | 36 (44) | 45 (55) | 63 (77)** | 34 (42) | 46 (56) | 62 (76)** |
| Other Lesions (in %)$$ | 1(1) | 1 (1) | 0 | 3 (4) | 3 (4) | 0 |
| Iridocyclitis (advanced stage) | 1 (1) | 2 (2) | 7 (9)** | 2 (2) | 3 (4) | 8 (10)** |
| Iridocyclitis (early stage) (in %) | 34 (42) | 21 (26) | 11 (13)** | 33 (40) | 19 (23) | 11(13)** |
| Iridocyclitis (torpide, in evolution)(in %) | 9 (11) | 12 (15) | 0* | 9 (11) | 10 (12) | 0* |
| Lens (Cataract) | ||||||
| Other Lesions non Cataract (in %) §§ | 3 (4) | 3 (4) | 3 (4) | 5 (6) | 5 (6) | 4 (5) |
| Cataract (early stage; PES clearly visible) (%) | 13 (16) | 14 (17) | 18 (22) | 13 (16) | 15 (18) | 18 (22) |
| Cataract (in evolution; PES difficult to examine) (in %) | 1 (1) | 4 (5) | 10 (12)** | 1 (1) | 4 (5) | 8 (10)** |
| Cataract (mature; PES not visible) (in %) | 2 (2) | 2 (2) | 9 (11) | 2 (2) | 0 | 10 (12)** |
| Lens Normal (in %) | 63 (77) | 59 (72) | 42 (51) | 61 (74) | 58 (71) | 42 (51) |
| Papillitis | ||||||
| Optic Disc Atrophy (secondary) (%) | 7 (8) | 10 (12) | 0* | 7 (9) | 11 (13) | 0* |
| Other Lesions (in %)&& | 1 (1) | 1 (1) | 12 (15)** | 0 | 1 (1) | 14 (17)** |
| Excavation (in %) | 2 (2) | 4 (5) | 4 (5) | 3 (4) | 3 (4) | 4 (5) |
| Impossible to examine (in %) | 0 | 3 (4) | 0 | 1 (1) | 3 (4) | 0 |
| Papille normal (in %) | 49 (60) | 60 (73)& | 46 (56) | 49 (60) | 59 (72)& | 45 (55) |
| Papillitis (avanced stage) (%) | 0 | 0 | 6 (7) | 0 | 0 | 4 (5) |
| Papillitis (early stage) (in %) | 23 (28) | 4 (5)& | 14 (17)** | 22 (27) | 5 (6)& | 15 (18)** |
| Chorioretinitis | ||||||
| Other Lesions (in %) §§§ | 1 (1) | 4 (5) | 5 (6) | 3 (4) | 4 (5) | 4 (5) |
| Chorioretinitis (advanced) (in %) | 15 (18) | 14 (17) | 17 (21) | 18 (22) | 19 (23) | 20 (24) |
| Chorioretinitis (early stage) (%) | 42 (51) | 38 (46) | 10 (12)** | 42 (51) | 35 (43) | 11 (13)** |
| Chorion Normal (in %) | 24 (30) | 26 (32) | 50 (61)** | 19 (23) | 24 (29) | 47 (57)** |
$
PIT = post initial treatment.
PES = Posterior Eye Segment.
$$
Other Lesions: Phtyse, Pupille scleroatrophic, Synechie post trauma, Pigments on posterior Capsule.
§§
Other Lesions: Phtyse, dead O.volvulus microfilariae on posterior capsule.
&&
Other Lesions: optic cup/disc >0.5.
§§§
Other Lesions = retina detachment from the retinal pigment epithelium, drusen.
*p<0.001 compared to 4 years PIT;
**p<0.001 compared to before ivermectin;
***p<0.0001 compared to before ivermectin and 4 years PIT.
&
p<0.01 compared to before ivermectin.