Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Mol Carcinog. 2013 Dec 2;54(7):513–522. doi: 10.1002/mc.22116

Figure 1. Alternative translation initiation codons in MLH1 and BRCA2.

Figure 1

A) Translation from all but one of these potential start codons (c.103) is predicted to result in an out-of-frame protein product. Two of the ATP-binding and hydrolysis domain motifs are shown (bases 91–129 and 187–204). Two further ATP-binding and hydrolysis motifs lie at bases 289–321 and 436–441. B) Alternative translation start sites following the aberrant splicing event as a result of BRCA2:c.67+3A>G are highlighted at position c.323 and c.367. The N-terminal transactivation domain that spans bases 67–315 is lost as a result of translation initiation at c.323 and c.367. In the event that the ATG at c.323 is recognized as the translation initiation signal, an out of frame protein would be synthesized terminating 12 amino acids after initiation. Initiation at c.367 would result in an in-frame protein product, lacking the N-terminal transactivation domain.