Table 4. Predictive value of cytokines for GNB in patients with sepsis or intracranial infection.

diagnostic indicators	AUC	SE a	95% CI b	Youden index J	Associated criterion (pg/mL)	Sensitivity (%)	Specificity (%)	Z statistic	Significance level
Derivation cohort (n = 342)
IL-2	0.581	0.0379	0.526 to 0.634	0.1677	≤1.7	41.80	75.00	1.394	0.1633*
IL-10	0.661	0.0398	0.608 to 0.712	0.3483	>58.5	43.00	91.80	0.156	0.8764*
CRP	0.654	0.0352	0.600 to 0.705	0.3171	>11.0	74.70	57.00
LOGREGR.Pred_IL-2+IL-10	0.735	0.0340	0.685 to 0.782	0.3687	IL-2<3.0 and IL-10>48.9	22.50	93.30	1.925	0.0542*
Validation cohort (n = 90)
IL-2	0.568	0.0427	0.503 to 0.631		≤1.7	41.10	72.69	1.154	0.2486*
IL-10	0.650	0.0412	0.592 to 0.705		>58.5	42.47	90.74	0.495	0.6207*
CRP	0.615	0.0410	0.551 to 0.677		>11.0	72.58	50.56
LOGREGR.Pred_IL-2+IL-10	0.711	0.0392	0.649 to 0.767		IL-2<3.0 and IL-10>48.9	18.52	96.83	1.902	0.0572*

^aDeLong et al., 1988.

^bBinomial exact.

*compared with CRP. LOGREGR?Pred_IL-2+IL-10 indicates the combination of IL-2 and IL-10.