Figure 2. Motif enrichment in histone modification data.

All motifs were significantly enriched in target over background sequences (p<0.01). Fold enrichment is indicated relative to background. (A,B) Top ranking motifs in both cell lines showed strong overlap (top 10). (C,D) Motifs that differed strongly between the cell lines with regard to their enrichments were selected. A motif was assessed favorably if its ranking was high (≤20) for one cell line and low for the other cell line (or was absent in the other list of enriched motifs). Score: The difference in ranking was assessed based on the difference in relative position in the list (|1-(r_TCam-2/n_TCam-2)–1-(r_NCCIT/n_NCCIT)|≥15%, n = nr of enriched motifs, r is the rank of a specific motif in the list of enriched motifs for either cell line).