Table 1.
Tissue characteristics in controls and patient groups
| CMR findings | Controls (n = 50) | All patients (n = 60) | Group I (Edema+, LGE+) (n = 41) | Group II (Edema-, LGE+) (n = 12) | Group III (Edema-, LGE-) (n = 7) |
|---|---|---|---|---|---|
| Ejection fraction (%) |
72 ± 6 |
64 ± 12* |
61 ± 13† |
70 ± 11 |
72 ± 6 |
| Global myocardial T2 SI ratio‡ |
1.56 ± 0.15 |
1.71 ± 0.27* |
1.79 ± 0.27† |
1.60 ± 0.16 |
1.47 ± 0.17 |
| Myocardial injury by T2 SI ratio ≥ 2.0 (%) |
0 (0 to 2) |
5 (1 to 18)* |
9 (3 to 22)† |
0.6 (0 to 4) |
0 (0 to 0) |
| Mean myocardial T1 (ms) |
946 ± 23 |
1011 ± 64* |
1030 ± 62† |
986 ± 54† |
947 ± 27 |
| Myocardial injury by T1 ≥ 990 ms (%) |
0.7 (0 to 3) |
32 (15 to 65)* |
49 (24 to 70)† |
15 (12 to 29)† |
6 (2 to 7)† |
| Myocardial injury by LGE (%)§ | 0 (0 to 1) (n = 35) | 11 (4 to 20)* | 16 (8 to 24)† | 7 (4 to 12)† | 1 (0 to 2) |
Values are presented as mean ± SD or median (interquartile range). *p < 0.001 when compared to controls.
In post-hoc subgroup analyses: †significantly different from controls;
areas of injury by T2 (edema) were significantly larger in Group I than Group II and III;
areas of injury by both T1 and LGE were significantly larger in Group I > II > III patients.
‡Global myocardial T2 SI ratio = T2 SI myocardium: sk. muscle
§LGE is detected when myocardial SI is ≥ 2.0 standard deviation above the mean SI of remote myocardium.