Table 2.
Multi-localization EGFR genotyping screening
| |
Number and type of samples analyzed per patients |
EGFR genotyping results |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Patients | Mutation type | Primary tumor(sugical sample,lung biopsy*,bronchial biospy£) | PLEURAL BIOPSY | LYMPH NODE | Cytology: Pleural Effusion,Bronchial aspiration* | Contributive samples | Concordant EGFR status | Non contributive samples | Discordant EGFR status |
| P1 |
del19 |
7 |
0 |
0 |
0 |
7 |
7 |
0 |
|
| P2 |
del19 |
2 |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P3 |
del19 |
0 |
3 |
0 |
1 |
4 |
3 |
0 |
1 (rescued by CAST PCR) |
| P4 |
del19 |
0 |
4 |
0 |
1 |
5 |
5 |
0 |
|
| P5 |
del19 |
0 |
3 |
0 |
1 |
4 |
4 |
0 |
|
| P6 |
del19 |
1* + 1* |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P7 |
del19 |
0 |
0 |
0 |
2 |
2 |
2 |
0 |
|
| P8 |
del19 |
1* + 1* |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P9 |
del19 |
3 |
1 |
0 |
0 |
4 |
4 |
0 |
|
| P10 |
del19 |
0 |
3 |
0 |
0 |
3 |
3 |
0 |
|
| P11 |
del19 |
0 |
3 |
0 |
0 |
3 |
3 |
0 |
|
| P12 |
del19 |
0 |
3 |
0 |
0 |
2 |
2 |
1 |
|
| P13 |
del19 |
4 |
0 |
0 |
0 |
4 |
4 |
0 |
|
| P14 |
del19 |
2 |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P15 |
del19 |
0 |
2 |
0 |
1 |
3 |
3 |
0 |
|
| P16 |
del19 |
1£ + 1£ |
0 |
0 |
1* |
3 |
1 |
0 |
2 (remained WT by CAST PCR) |
| P17 |
del19 |
3 |
0 |
0 |
0 |
3 |
3 |
0 |
|
| P18 |
del19 |
0 |
0 |
1 |
1* |
1 |
1 |
1 |
|
| P19 |
del19 |
1 + 1* |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P20 |
p.G719A |
1 |
0 |
4 |
0 |
5 |
5 |
0 |
|
| P21 |
p.G719A |
5 |
0 |
2 |
0 |
7 |
7 |
0 |
|
| P22 |
ins20 |
3 |
0 |
1 |
0 |
4 |
4 |
0 |
|
| P23 |
ins20 |
0 |
2 |
0 |
0 |
2 |
2 |
0 |
|
| P24 |
ins20 |
3 |
0 |
2 |
0 |
4 |
4 |
1 |
|
| P25 |
ins20 |
0 |
2 |
0 |
0 |
2 |
2 |
0 |
|
| P26 |
ins20 |
3 |
0 |
0 |
0 |
3 |
3 |
0 |
|
| P27 |
ins20 |
2 + 1 |
0 |
1 + 1 |
0 |
4 |
2 |
1 |
2 |
| P28 |
p.L858R |
4 |
0 |
2 |
0 |
6 |
6 |
0 |
|
| P29 |
p.L858R |
1£ + 1£ |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P30 |
p.L858R |
2 |
0 |
0 |
0 |
2 |
2 |
0 |
|
| P31 |
p.L858R |
3 |
0 |
0 |
0 |
3 |
3 |
0 |
|
| P32 |
p.L858R |
0 |
3 |
0 |
1 |
4 |
4 |
0 |
|
| P33 |
p.L858R |
0 |
3 |
0 |
0 |
3 |
3 |
0 |
|
| P34 |
p.L858R |
1£ |
1 |
0 |
1 |
3 |
3 |
0 |
|
| P35 |
p.L858R |
4 |
0 |
2 |
0 |
6 |
6 |
0 |
|
| P36 |
p.L858R |
2 |
0 |
1 |
0 |
3 |
3 |
0 |
|
| P37 |
p.L858R |
3 |
0 |
0 |
0 |
3 |
3 |
0 |
|
| P38 |
p.L858R |
3 |
0 |
0 |
0 |
3 |
3 |
0 |
|
| P39 |
p.L858R |
3 |
0 |
0 |
0 |
3 |
3 |
0 |
|
| P40 | p.L861Q/p.T790M | 19 | 0 | 0 | 0 | 19 | 19 | 0 | |
Shows the type and number of samples tested for EGFR mutation in 40 patients. Non-contributive samples are non-amplified specimens. Discordant samples are DNAs that have been found wild type when a mutation was expected. The discordant samples are italic. Lung biopsy: *and bronchial biopsy: £.