Table 3.
Multi-localization EGFR CNV screening
| |
Number and type of samples analyzed per patients |
EGFR
CNV results |
||||||
|---|---|---|---|---|---|---|---|---|
| Patients | Mutation type | Primary tumor(sugical sample,lung biopsy*, bronchial biospy£ | Pleural biopsy | Lymph node | Cytology: Pleural effusion,Bronchial Aspiration* | EGFR CNV ≥ 2.5 | EGFR CNV < 2.5 | Non contributive samples |
|
P1 |
del19 |
7 |
0 |
0 |
0 |
5 |
2 |
|
|
P2 |
del19 |
2 |
0 |
0 |
0 |
|
2 |
|
|
P3 |
del19 |
0 |
3 |
0 |
1 |
|
3 |
1 |
|
P4 |
del19 |
0 |
4 |
0 |
1 |
1 |
3 |
1 |
|
P5 |
del19 |
0 |
3 |
0 |
1 |
1 |
3 |
|
|
P6 |
del19 |
1* + 1* |
0 |
0 |
0 |
1 |
1 |
|
|
P7 |
del19 |
0 |
0 |
0 |
2 |
1 |
1 |
|
|
P8 |
del19 |
1* + 1* |
0 |
0 |
0 |
1 |
1 |
|
|
P9 |
del19 |
3 |
1 |
0 |
0 |
1 |
3 |
|
|
P10 |
del19 |
0 |
3 |
0 |
0 |
|
1 |
2 |
|
P11 |
del19 |
0 |
3 |
0 |
0 |
3 |
|
|
|
P12 |
del19 |
0 |
3 |
0 |
0 |
1 |
2 |
|
|
P13 |
del19 |
4 |
0 |
0 |
0 |
|
4 |
|
|
P14 |
del19 |
2 |
0 |
0 |
0 |
|
2 |
|
|
P15 |
del19 |
0 |
2 |
0 |
1 |
|
3 |
|
|
P16 |
del19 |
1£ + 1£ |
0 |
0 |
1* |
|
1 |
2 |
|
P17 |
del19 |
3 |
0 |
0 |
0 |
1 |
1 |
1 |
|
P18 |
del19 |
0 |
0 |
1 |
1* |
|
1 |
1 |
|
P19 |
del19 |
1 + 1* |
0 |
0 |
0 |
|
1 |
1 |
|
P20 |
p.G719A |
1 |
0 |
4 |
0 |
1 |
2 |
2 |
|
P21 |
p.G719A |
5 |
0 |
2 |
0 |
|
6 |
1 |
|
P22 |
ins20 |
3 |
0 |
1 |
0 |
2 |
2 |
|
|
P23 |
ins20 |
0 |
2 |
0 |
0 |
|
2 |
|
|
P24 |
ins20 |
3 |
0 |
2 |
0 |
|
4 |
1 |
|
P25 |
ins20 |
0 |
2 |
0 |
0 |
1 |
1 |
|
|
P26 |
ins20 |
3 |
0 |
0 |
0 |
|
3 |
|
|
P27 |
ins20 |
2 + 1 |
0 |
1 + 1 |
0 |
|
4 |
1 |
|
P28 |
p.L858R |
4 |
0 |
2 |
0 |
|
6 |
|
|
P29 |
p.L858R |
1£ + 1£ |
0 |
0 |
0 |
1 |
1 |
|
|
P30 |
p.L858R |
2 |
0 |
0 |
0 |
|
2 |
|
|
P31 |
p.L858R |
3 |
0 |
0 |
0 |
|
3 |
|
|
P32 |
p.L858R |
0 |
3 |
0 |
1 |
2 |
2 |
|
|
P33 |
p.L858R |
0 |
3 |
0 |
0 |
1 |
1 |
1 |
|
P34 |
p.L858R |
1£ |
1 |
0 |
1 |
1 |
|
2 |
|
P35 |
p.L858R |
4 |
0 |
2 |
0 |
|
6 |
|
|
P36 |
p.L858R |
2 |
0 |
1 |
0 |
|
2 |
1 |
|
P37 |
p.L858R |
3 |
0 |
0 |
0 |
|
2 |
1 |
|
P38 |
p.L858R |
3 |
0 |
0 |
0 |
1 |
2 |
|
|
P39 |
p.L858R |
3 |
0 |
0 |
0 |
|
2 |
1 |
| P40 | p.L861Q/p.T790M | 19 | 0 | 0 | 0 | 18 | 1 | |
Shows the type and number of samples tested for EGFR copy number variation (CNV) in 40 patients. Non-contributive samples are non-amplified specimens or samples with Ct >30.
Lung biopsy: * and bronchial biopsy: £.