Fig. 1.

Ventral aspect of high fat-fed mice sham-treated (control) or treated with heat shock and mild electrical stimulation [42 °C electrodes and 12 V direct current (55 pps of 0.1 ms duration) 10 min, two times per week] after 15 weeks of treatment with exposed peritoneal cavity, showing decrease in visible adipose tissues in treated mice. The diet induced t2DM phenotype is normalized by therapy [from open access journal, Plos1 (Morino et al. 2008)]. Similarly, but not shown here, heme oxygenase stimulation with cobalt protoporphyrin in the Zucker fat rat alters the t2DM phenotype to a thin, smaller rat (Nicolai et al. 2009)