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. 2014 May 13;3(5):e162. doi: 10.1038/mtna.2014.14

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Characterization of HNB-LCD for the expansion of the short-interfering RNA (siRNA) delivery therapeutic window. (a) Varying amounts of HNB-LCD were added to A431 cells treated with 100 nmol/l E6N2/siRNA-Alexa 488 complexes for 6 hours. siRNA uptake was normalized to uptake by E6N2/siRNA-Alexa 488 in the absence of HNB-LCD (data shown as mean ± SD, n = 6). (b) The therapeutic window for D-PFO was determined for A431-d2EGFP cells in the presence of 7.5 nmol/l HNB-LCD and 100 nmol/l E6N2/siRNA complexes (data shown as mean ± SD, n = 9). (c) The potency of E6N2/siGFP is measured in a GFP knockdown assay in the presence of 100 pmol/l D-PFO and 7.5 nmol/l HNB-LCD (data shown as mean ± SD, n = 9). Cell viability and GFP expression are normalized as in Figure 3.