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. 2014 May 28;5:253. doi: 10.3389/fmicb.2014.00253

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Copyright © 2014 Alfadhli and Barklis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chaperone model for MA–RNA binding. The chaperone model for MA-RNA binding posits that both the MA and NC domains of PrGag proteins bind to RNA in the cytoplasm of infected cells, and that the MA–RNA binding protects MA from binding to inappropriate intracellular membranes, lacking PI(4,5)P2. Once at PI(4,5)P2-rich sites at the plasma membrane, MA binding switches from RNA to PI(4,5)P2, facilitating the trafficking and assembly of PrGag proteins.