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. 2014 May 28;5:253. doi: 10.3389/fmicb.2014.00253

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Copyright © 2014 Alfadhli and Barklis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overlap of matrix RNA and PI(4,5)P2 binding sites. The membrane-binding surface of the HIV-1 matrix protein (PDB 1UPH) is illustrated as a space-filling model. Residues that have been implicated in PI(4,5)P2 binding are indicated in blue, residues that have been implicated in RNA binding (Alfadhli et al., 2011) are indicated in red, and residues that have been implicated in both PI(4,5)P2 and RNA binding are indicated in purple.