Table I.
Heart failure parameters
| Index | Control group (n = 6) | HF group (n = 8) | HF + rotigaptide group (n = 6) |
|---|---|---|---|
| BW [kg] | 3.5 ±0.1 | 2.6 ±0.2* | 2.8 ±0.2* |
| LVW [g] | 3.6 ±0.1 | 6.2 ±0.3* | 6.2 ±0.5* |
| LVW/BW [g/kg] | 1.0 ±0.1 | 2.4 ±0.2* | 2.3 ±0.2* |
| LVEDD [cm] | 1.5 ±0.2 | 2.3 ±0.2* | 2.4 ±0.5* |
| LVESD [cm] | 0.9 ±0.1 | 1.9 ±0.2* | 1.9 ±0.4* |
| LVEDV [ml] | 6.0 ±1.7 | 18.3 ±3.8* | 22.0 ±9.9* |
| LVESV [ml] | 1.4 ±0.5 | 10.8 ±2.3* | 12.7 ±6.5* |
| LVEF [%] | 75.3 ±4.1 | 38.9 ±3.3* | 38.4 ±6.9* |
| LV FS [%] | 40.9 ±3.6 | 17.4 ±2.5* | 17.3 ±3.2* |
Values are mean ± SD. HF – heart failure, BW – body weight, LVW – left ventricle weight, LVEDD – left ventricular end-diastolic dimension, LVESD – left ventricular end-systolic dimension, LVEDV – left ventricular end-diastolic volume, LVESV – left ventricular end-systolic volume, LVEF – left ventricular ejection fraction, LVFS – left ventricular fractional shortening. Compared with control group
*
p < 0.05