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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 May 16;132(2):437–445. doi: 10.1016/j.jaci.2013.03.024

Figure 1. Siglec-8 crosslinking induces a different mode of cell death in activated versus resting eosinophils.

Figure 1

A, Representative morphology and the percentage of dead cells that have apoptotic or necrotic morphology in eosinophils cultured for 24 hours with indicated stimuli (n= 6 experiments and donors). B, Mean percentage of dead cells with necrotic morphology in multiple experiments (n = 6). #p = 0.055. C, Representative Annexin V/7AAD staining and the percent of 7AAD+ and 7AAD−cells among all Annexin V+ cells. D, Mean ratio of 7AAD+ cells among all Annexin V+ cells from multiple experiments (n = 25 experiments with 11 donors; **p <0.01). E, activity of released EPO following incubation with indicated stimuli for 4-hours (left) or over 16 hours (right).