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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 May 16;132(2):437–445. doi: 10.1016/j.jaci.2013.03.024

Figure 4. Upregulation of MEK/ERK pathway is required for enhanced cell death induced by anti-Siglec-8/IL-5 co-stimulation.

Figure 4

Eosinophils were pre-incubated with A) U0126 or B) PD184352 at the indicated doses and then cultured in media containing IL-5 ± anti-Siglec-8. Annexin V+ and/or 7AAD+ cells were determined after 24 hours. Shown are representative data from 3 experiments with each inhibitor. *p <0.01 and §p <0.01, compared to % Annexin V+ 7AAD+ and % Annexin V+ 7AAD−, respectively, in IL-5 + anti-Siglec-8 treated cells without inhibitors.