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. 2014 Apr 25;28(6):860–871. doi: 10.1210/me.2014-1038

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Copyright © 2014 by the Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the Endocrine Society the exclusive right to publish the article and identify itself as the original publisher.

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Figure 6. — Schematic of GLP-1-modulated beta cell energetics. Glycolytic metabolism of glucose stimulates insulin secretion through increases in [ATP/ADP]_cyto and cAMP, leading to opening of VDCC and Ca²⁺ influx, the latter reinforcing ATP synthesis. GLP-1 augments glucose-stimulated insulin secretion by increasing cAMP input, leading to potentiated [ATP/ADP]_cyto rises and Ca²⁺ influx.