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A diagram of the proposed androgen-dependent cell proliferation mediated by SGK3 in AR-positive prostate cancer. SGK3 is induced by androgen/AR through a transcriptional mechanism and is activated by phosphoinositide-dependent kinase-1 (PDK1) downstream of PI3K. Activated SGK3 promotes prostate cancer cell proliferation through up-regulation of mTORC1/p70S6K signaling and a subsequent increase in cyclin D1 levels.
