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Mechanisms of modulation of TR4 activity by phosphorylation and acetylation. A, Phosphorylation of the TR4 AF-1 domain leads to recruitment of the corepressor complex that inhibits transcription initiation. B, Dephosphorylated TR4 recruits coactivator complex that promote transcription initiation. C, Acetylation of TR4 at the DBD prevents TR4-binding to HRE and inhibits transcription initiation.
