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Activation of the Rho kinase (ROCK)/Lim kinase (LIMK)/cofilin pathway during FSS to form ASFF in osteoblasts. The presence of phosphorylated cofilin (P-cofilin) (right) was increased after 15 min treatment with 1 μM LPA under static conditions, as well as after 15 min of FSS (12 dyn/cm2). Inhibition of ROCK during FSS with 10 μM Y27632 attenuated the presence of P-cofilin. A similar response was observed in LIMK-2 phosphorylation under the same conditions (left). Bar indicates 20 μm.
