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. 2014 Apr 17;306(11):G992–G1001. doi: 10.1152/ajpgi.00016.2014

Fig. 3.

Fig. 3.

C12-HSL increases activity of matrix metalloprotease (MMP)-2 and MMP-3. Cells were incubated with 200 μM C12-HSL for the indicated time points (A and C) or with the indicated concentrations of C12-HSL for 4 h (B and D). Controls were either untreated (CTL) or incubated with 0.4% DMSO (B and D) or 0.2% DMSO (A and C) as vehicle (Veh). MMP-2 (A and B) and MMP-3 (C and D) activity was determined by using activity assay kits and zymography (blots in B and D). Values are means ± SD; n ≥ 4. **P < 0.01, ***P < 0.001 vs. CTL (B and D) or Veh (A and C) at the indicated time points.