Table 2.
A summary of frequent combinations and genes in conditions from our study and from other studies.
| Gene or combination | Common in our study in | Appeared in the literature in relation to |
|---|---|---|
| VH1-2 | MALT-La | Self-reactive antibodies, Bahler et al. (44) |
| Chronic lymphocytic leukemia (B-CLL), primary central nervous system lymphomas, and splenic marginal zone lymphomas, Walsh and Rosenquist (45) | ||
| VH1-3 | GNHP, GHP | B-CLL, Fais et al. (46) |
| VH1-18 | GNHP, GHP, DLBCL | B-CLL, Fais et al. (46) |
| Autoreactive gene, Yamashita et al. (47) | ||
| BM-DLBCL, gastric MALT-Ls, Bende et al. (48) | ||
| VH1-8 | DLBCL | B-CLL, Pimentel et al. (49) |
| VH1-69 | MALT-La, DLBCL | Rheumatoid factor, Bende et al. (48), Matsuda et al. (50) |
| Gastric MALT-Ls, Bende et al. (48) | ||
| B-CLL, Fais et al. (46), Pimentel et al. (49), Johnson et al. (51) | ||
| VH2-26/JH5 | MALT-La | FL, Bayerl et al. (52) |
| VH2-26 | MALT-La | B-CLL, Pimentel et al. (49) |
| Hairy cell leukemia, Hashimoto et al. (53) | ||
| VH3-7 | MALT-L Dominant, DLBCL | Rheumatoid factor, Bende et al. (48), Matsuda et al. (50) |
| Rheumatoid arthritis, Nakamura-Kikuoka et al. (54) | ||
| Sjögren syndrome, Bahler and Swerdlow (55) | ||
| B-CLL, Fais et al. (46) | ||
| BM-DLBCL, Yamashita et al. (47) | ||
| Gastric MALT-Ls, Bende et al. (48) | ||
| VH3-23 | DLBCL | IgM+ B-cells, Brezinschek et al. (56) |
| Naïve B-cells, Wu et al. (57) | ||
| Anti-DNA auto-antibodies, Matsuda et al. (50) | ||
| Hepatitis C virus-related mixed cryoglobulinemia, Perotti et al. (58) | ||
| Unmutated VH3-23 in transformation from B-CLL into DLBCL, Mao et al. (59) | ||
| Gastric MALT lymphomagenesis, Sakuma et al. (60), Lenze et al. (61), Alpen et al. (62), Siakantaris et al. (63) | ||
| BM-DLBCL, Yamashita et al. (47) | ||
| B-CLL, Pimentel et al. (49) | ||
| VH3-30 | DLBCL | Rheumatoid factor, Bende et al. (48), Matsuda et al. (50) |
| Gastric MALT lymphomagenesis, Sakuma et al. (60), Lenze et al. (61), Alpen et al. (62), Siakantaris et al. (63) | ||
| B-CLL, Pimentel et al. (49) | ||
| VH3-30/JH4 | DLBCL | FL, Bayerl et al. (52) |
| VH5-51 and VH6-1 | CLN, GNHP, GHP, and DLBCL | Auto-antigens, Matsuda et al. (50) |
| Dominant |
The dominant segments are marked with “Dominant” indication. The dominant segments/combinations are those that appeared in the largest clone in each sample.
aRepresents frequent genes or combinations in the repertoire of unique sequences.