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. 2014 Jun 3;6:103. doi: 10.3389/fnagi.2014.00103

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Copyright © 2014 Chen, Liu, Zhu, Chen, Hu, Jiang, Xu, Wang, Zhou, Chen, Zhang, Hu, Zhang, Wang, Xu, Wu, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIRT1 positively regulates P16 and P21 expression in MSCs. SIRT1 knockdown in young MSCs was associated with increases in P16 and P21 expression, with representative protein bands shown in (A) and quantified in a bar graph shown in (B). In contrast, SIRT1 overexpression in aged MSCs decreases P16 and P21 expressions. Representative western blot images (C) and the quantitative analysis results (D) were shown. Data are expressed as mean ± SD (three independent experiments, n = 5 rats/group). ^*Implies P < 0.05, compared to mock-young MSCs. #, P < 0.05, compared to vector-aged MSCs.