Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 3;6:103. doi: 10.3389/fnagi.2014.00103

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Chen, Liu, Zhu, Chen, Hu, Jiang, Xu, Wang, Zhou, Chen, Zhang, Hu, Zhang, Wang, Xu, Wu, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SIRT1 protects telomere DNA damage in MSCs. Representative immunofluorescence images of young (mock- and shSIRT1-) and aged MSCs (vector- and SIRT1) stained with γ-H2AX (Green), TRF2 (Red), and DAPI (Blue) (A). Quantitative analysis of γ-H2AX foci in young (mock- and shSIRT1-) (B) and aged MSCs (vector- and SIRT1-) (C) were shown. A cell was considered TIF positive if ≥50% of its γ-H2AX foci were associated with TRF2 (as shown in merged image). Quantitative analysis of TIF positive cells in young (mock- and shSIRT1-) (D) and aged MSCs (vector- and SIRT1-) (E) were shown. Data are expressed as mean ± SD (three independent experiments, n = 5 rats/group). ^*Implies P < 0.05, compared to mock-young MSCs. #, P < 0.05, compared to vector-aged MSCs.