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. 2014 May 20;24(6):651–664. doi: 10.1038/cr.2014.65

Figure 4.

Figure 4

A simplified summary of IgG-BCR-intrinsic and -extrinsic factors that work together to enhance the activation and differentiation of memory B cells. Most of the IgG-BCR-intrinsic and -extrinsic factors discussed in this review are depicted in this cartoon to show their potential location and interacting proteins in enhancing the activation and differentiation of IgG-BCR-expressing memory B cells, but not IgM-BCR-expressing mature naïve B cells. IgG-BCR-intrinsic factors likely involve the adaptor protein Grb2 recruited through the membrane distal ITT motif and the scaffolding protein SAP97 recruited through the membrane-proximal SSVV motif of mIgG cytoplasmic tail. These IgG-BCR-intrinsic factors may be responsible for the enhanced calcium responses through some unidentified mechanisms. IgG-BCR-extrinsic factors likely involve the transcription factor Bach2, the expression of which is repressed in IgG-BCR-expressing memory B cells but not in IgM-BCR-expressing mature naïve B cells. The repression of Bach2 in memory B cells is required for enhanced plasma cell differentiation of these cells.