Table 3.

Top 15 up- and downregulated mRNA transcripts in obese pigs based on average RPKM values for obese and lean groups

	Gene Name	Lean RPKM	Obese RPKM	Fold Change	P Value
Top 15 Upregulated mRNAs in Obese Pigs
CYP4B1	cytochrome P450, family 4, subfamily B, polypeptide 1	20.14	88.89	4.41	<0.001
Contig 17371		31.44	93.39	2.97	0.01
MYO9A	myosin IXA	67.89	192.62	2.84	<0.001
LRRN4CL	LRRN4 COOH-terminal like	51.48	138.08	2.68	0.002
MLL2	myeloid/lymphoid 2	2.51	6.61	2.63	<0.001
GRP35	G protein-coupled receptor 35	3.80	9.95	2.62	<0.001
PDGFRA	platelet-derived growth factor receptor-α	5.77	14.84	2.57	0.01
Contig 57707		4.07	9.58	2.35	0.01
PEAK1	NKF3 kinase family member	2.76	6.12	2.22	<0.001
ATF3	activating transcription factor 3	3.05	6.74	2.21	0.01
KLF11	kruppel-like factor 11	5.20	11.45	2.20	0.02
TMEM245	transmembrane protein 245	16.15	35.22	2.18	0.03
MTRNR2L8	MT-RNR2-like 8	78.10	169.00	2.16	0.03
OAS1	2′-5′-oligoadenylate synthetase 1	12.05	25.97	2.16	<0.001
MAFF	V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	5.05	10.45	2.06	0.02
Top 15 Downregulated mRNAs in Obese Pigs
GLUL	glutamate-ammonia ligase	22.77	10.10	−2.46	0.02
HOXB6	homeobox B6	2.13	4.79	−2.24	0.01
PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	7.30	3.28	−2.22	0.01
RASAL2	RAS protein activator like 2	4.59	2.10	−2.18	<0.001
Contig 107117		35.26	16.15	−2.18	0.01
Contig 117398		4.89	2.27	−2.15	0.02
INSIG1	insulin induced gene 1	5.43	2.53	−2.12	0.01
ZMYM6NB	ZMYM6 neighbor	4.55	2.15	−2.11	0.02
F5	coagulation factor V	11.74	5.58	−2.10	0.02
Contig 43106		5.93	2.87	−2.07	0.02
HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	4.83	2.34	−2.06	0.03
Contig 56089		4.06	2.13	−2.05	0.003
AACS	acetoacetyl-CoA synthetase	36.05	17.82	−2.02	<0.001
LOC100506127	putative uncharacterized protein FLJ37770-like	6.07	3.01	−2.02	0.005
SERPINI1	serpin peptidase inhibitor, Clade 1	5.73	2.85	−2.00	0.03

RPKM, reads per kilobase per million reads. Fold change calculated as obese/lean.